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Asthma

Core of basic research: Explore the immune imbalance mechanism dominated by Th2 cells, focusing on the driving role of cytokines such as IL-4/IL-5/IL-13 in airway inflammation, as well as the molecular basis of IgE-mediated mast cell activation and airway epithelial cell hyperresponsiveness.
Core key proteins: IL-4/IL-5/IL-13 (Th2-type cytokines driving inflammation), IgE (mediates antigen recognition and mast cell activation), FcεRI (IgE receptor activating signal transduction), TNF-α (enhances inflammatory responses), IFN-γ (Th1-type cytokine regulating immune balance), STAT6 (mediates IL-4 signaling to regulate IgE synthesis), GATA3 (transcription factor for Th2 cell differentiation), TLR4 (recognizes pathogens to initiate inflammation).

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