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Cat No: AH0001
Size
Price
Inventory
Number
20ul
$108.00
In stock
0
40ul
$200.00
In stock
0
100ul
$416.00
In stock
0
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Collection
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Main information
Target
PD1
Reactivity
Human
Applications
IHC,IF,ELISA
MW (kDa)
32kD（ Calculated）
56kD（ Observed）
Host Species
Mouse
Isotype
IgG1,Kappa
Detailed information
Reactivity
IHC 1:200-400
IF 1:200-1:1000
ELISA 1:500-5000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
Validation Strategies
Specificity
The antibody can specifically recognize human PD-1 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
MW(Calculated)
32kD
MW(Observed)
56kD
Clonality
Monoclonal
Clone
M699V
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Antigen & target information
Immunogen:
Synthesized peptide derived from human PD-1 AA range: 1-100
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Gene Name:
PDCD1 PD1
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Protein Name:
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
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Cell localization
Membranous, Cytoplasmic
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Tissue Expression
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Background
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
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Function
developmental stage:Induced at programmed cell death.,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
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Research Areas
>> >>Cell adhesion molecules ;
>> >>T cell receptor signaling pathway ;
>> >>PD-L1 expression and PD-1 checkpoint pathway in cancer
>> >>T cell receptor signaling pathway ;
>> >>PD-L1 expression and PD-1 checkpoint pathway in cancer
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Signal Pathway
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