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Pathways in cancer
Core of basic research: Decipher the abnormal crosstalk mechanisms of core signaling pathways (proliferation, apoptosis, migration, angiogenesis) in tumor development and progression, explore the synergistic effects between pathways (e.g., crosstalk between PI3K-Akt and MAPK pathways), providing a theoretical basis for multi-target combination therapy.
Core key proteins: PI3K-Akt pathway (PI3K, Akt, mTOR, PTEN), MAPK pathway (Ras, Raf, MEK, ERK), Wnt pathway (β-Catenin, APC, GSK3β), NF-κB pathway (p65, IκBα, regulating inflammation and survival), VEGF pathway (VEGF, VEGFR, promoting angiogenesis).
Core key proteins: PI3K-Akt pathway (PI3K, Akt, mTOR, PTEN), MAPK pathway (Ras, Raf, MEK, ERK), Wnt pathway (β-Catenin, APC, GSK3β), NF-κB pathway (p65, IκBα, regulating inflammation and survival), VEGF pathway (VEGF, VEGFR, promoting angiogenesis).
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