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Thyroid cancer
Core of basic research: Focus on the abnormal activation of the MAPK pathway (BRAF V600E, RET/PTC fusion, RAS), explore the expression regulation of iodine metabolism-related genes (TTF-1, Pax8), and the molecular characteristic differences among subtypes (papillary carcinoma, follicular carcinoma, medullary carcinoma, anaplastic carcinoma).
Core key proteins: BRAF V600E (high-frequency mutation in papillary carcinoma), RET/PTC fusion protein (activates MAPK pathway), RAS (small GTPase driving pathway upon mutation), PI3K/Akt/mTOR (signaling pathway enhancing su
Core key proteins: BRAF V600E (high-frequency mutation in papillary carcinoma), RET/PTC fusion protein (activates MAPK pathway), RAS (small GTPase driving pathway upon mutation), PI3K/Akt/mTOR (signaling pathway enhancing su
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