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Small cell lung cancer
Core of basic research: Explore the regulatory mechanisms of neuroendocrine differentiation-related genes (ASCL1, NEUROD1), decipher the carcinogenic effects of MYC amplification and TP53/RB1 dual inactivation, as well as the molecular basis of SCLC's sensitivity to chemotherapy but rapid development of resistance.
Core key proteins: MYC (transcription factor, amplification promotes proliferation), ASCL1/NEUROD1 (neuroendocrine differentiation regulators), NOTCH1 (regulates cell fate), TP53/RB1 (dual tumor suppressor genes, characteristic of concurrent inactivation), VEGF (angiogenesis), PD-L1 (immune escape), Bcl-2 (anti-apoptotic protein), PARP (DNA repair enzyme as targeted therapy target).
Core key proteins: MYC (transcription factor, amplification promotes proliferation), ASCL1/NEUROD1 (neuroendocrine differentiation regulators), NOTCH1 (regulates cell fate), TP53/RB1 (dual tumor suppressor genes, characteristic of concurrent inactivation), VEGF (angiogenesis), PD-L1 (immune escape), Bcl-2 (anti-apoptotic protein), PARP (DNA repair enzyme as targeted therapy target).
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